Improving 3D reconstructions of macromolecular conformations
نویسندگان
چکیده
منابع مشابه
Improving 3D Genome Reconstructions Using Orthologous and Functional Constraints
The study of the 3D architecture of chromosomes has been advancing rapidly in recent years. While a number of methods for 3D reconstruction of genomic models based on Hi-C data were proposed, most of the analyses in the field have been performed on different 3D representation forms (such as graphs). Here, we reproduce most of the previous results on the 3D genomic organization of the eukaryote ...
متن کاملRefinement of protein conformations using a macromolecular energy minimization procedure.
This paper presents a rapid refinement procedure capable of deriving the stable conformation of a macromolecule from experimental model co-ordinates. All the degrees of freedom of the molecule are allowed to vary and all parts of the structure are refined simultaneously in a general force-field. The procedure has been applied to myoglobin and lysozyme. The deviations of peptide bonds from plana...
متن کاملConformations and 3D pharmacophore searching
Several methods have been developed and published over the past years to generate sets of diverse and pharmacologically relevant conformations which can be used within 3D pharmacophore search protocols to increase the number of meaningful hits of such experiments. This review gives some insights into the general challenges and problems in the area of 3D structure and conformation generation and...
متن کاملReproducibility of 3D chromatin configuration reconstructions.
It is widely recognized that the three-dimensional (3D) architecture of eukaryotic chromatin plays an important role in processes such as gene regulation and cancer-driving gene fusions. Observing or inferring this 3D structure at even modest resolutions had been problematic, since genomes are highly condensed and traditional assays are coarse. However, recently devised high-throughput molecula...
متن کاملLarge-Scale Texturing of 3D Reconstructions
3D reconstruction pipelines using structure-from-motion and multi-view stereo techniques are today able to reconstruct impressive, large-scale geometry models from images but do not yield textured results. Current texture creation methods are unable to handle the complexity and scale of these models. We therefore present the first comprehensive texturing framework for large-scale, real-world 3D...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations and Advances
سال: 2018
ISSN: 2053-2733
DOI: 10.1107/s0108767318098446